Detection of CTX-M-15 extended-spectrum -lactamase in the United Kingdom
2003; Oxford University Press; Volume: 52; Issue: 3 Linguagem: Inglês
10.1093/jac/dkg353
ISSN1460-2091
Autores Tópico(s)Pneumonia and Respiratory Infections
Resumo5282 mg/L with MIC 50 = 0.5 mg/L and MIC 90 = 2.0 mg/L.MBCs for 10 of 12 (83%) isolates were 2-4 times the MIC, indicating bactericidal effect.Plots of time-kill assays for two isolates with levofloxacin MICs = 0.5 mg/L and MBCs = 2 mg/L (4× MIC) are shown in Figure 1.Bactericidal effect for time-kill assays (99.9% killing) or reduction in inoculum by ≥3 log 10 dilutions occurred after 24 h at 8× MIC in one isolate and after 48 h in both isolates at concentrations ≥2× MIC.No regrowth exceeding 10 2 cfu/mL was observed.This is the first report describing MICs, MBCs and time-kill assays to assess bactericidal activity of levofloxacin against M. pneumoniae in the largest collection of clinical isolates reported to date.In 10 out of 12 randomly selected isolates, a bactericidal effect was demonstrated, supporting the use of levofloxacin against M. pneumoniae infections, including serious infections in which killing the organism may be of importance.
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