Strategies for the development of enantioselective catalysts
1999; International Union of Pure and Applied Chemistry; Volume: 71; Issue: 8 Linguagem: Inglês
10.1351/pac199971081503
ISSN1365-3075
Autores Tópico(s)Chemical Synthesis and Analysis
ResumoNovel C2-symmetric diiminosphosphoranes and diketimines are useful ligands for Pd-and Cu-catalyzed C-C bond forming reactions, Angermund's molecular modeling based on accessible molecular surface serving as a guide in predicting catalyst activity. The first highly enantioselective diphosphites as ligands in Rh-catalyzed hydrogenation are also described, the selectivity principle being based on in situ selection of conformational enantiomers. Finally, a systematic study of chiral diphosphonites reveals that ferrocene-based derivatives are ideal in hydrogenation and certain conjugate addition reactions. These methods are compared to biocatalytic strategies based on the creation of enantioselective biocatalysts by in vitro evolution, a rational process which is independent of the catalyst structure or mechanism.
Referência(s)