A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle
2014; Royal Society of Chemistry; Volume: 5; Issue: 7 Linguagem: Inglês
10.1039/c4fo00258j
ISSN2042-650X
AutoresMarta Oliveira, Filipa S. Reis, Diana Sousa, Catarina Tavares, Raquel T. Lima, Isabel C.F.R. Ferreira, Tiago dos Santos, M. Helena Vasconcelos,
Tópico(s)Polysaccharides and Plant Cell Walls
ResumoGanoderma lucidum is one of the most extensively studied mushrooms as a functional food and as a chemopreventive agent due to its recognized medicinal properties. Some G. lucidum extracts have shown promising antitumor potential. In this study, the bioactive properties of various extracts of G. lucidum, from both the fruiting body and the spores, were investigated. The most potent extract identified was the methanolic fruiting body extract, which inhibited the growth of a gastric cancer cell line (AGS) by interfering with cellular autophagy and cell cycle.
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