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Synthesis, Structural Characterisation and Quadruplex DNA Binding Studies of a New Gold(III) Pyrazolylpyridine Complex

2010; Wiley; Volume: 16; Issue: 12 Linguagem: Inglês

10.1002/chem.200903501

1521-3765

Kogularamanan Suntharalingam, Deepali Gupta, Pablo J. Sanz Miguel, Bernhard Lippert, Ramón Vilar,

Metal complexes synthesis and properties

Chemistry – A European JournalVolume 16, Issue 12 p. 3613-3616 Communication Synthesis, Structural Characterisation and Quadruplex DNA Binding Studies of a New Gold(III) Pyrazolylpyridine Complex Kogularamanan Suntharalingam, Kogularamanan Suntharalingam Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ (UK), Fax: (+44) 2075-941139Search for more papers by this authorDeepali Gupta Dr., Deepali Gupta Dr. Fakultät Chemie, Technische Universität Dortmund, 44221 Dortmund (Germany), Fax: (+49) 231-755-3797Search for more papers by this authorPablo J. Sanz Miguel Dr., Pablo J. Sanz Miguel Dr. Fakultät Chemie, Technische Universität Dortmund, 44221 Dortmund (Germany), Fax: (+49) 231-755-3797Search for more papers by this authorBernhard Lippert Prof. Dr., Bernhard Lippert Prof. Dr. [email protected] Fakultät Chemie, Technische Universität Dortmund, 44221 Dortmund (Germany), Fax: (+49) 231-755-3797Search for more papers by this authorRamon Vilar Dr., Ramon Vilar Dr. [email protected] Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ (UK), Fax: (+44) 2075-941139Search for more papers by this author Kogularamanan Suntharalingam, Kogularamanan Suntharalingam Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ (UK), Fax: (+44) 2075-941139Search for more papers by this authorDeepali Gupta Dr., Deepali Gupta Dr. Fakultät Chemie, Technische Universität Dortmund, 44221 Dortmund (Germany), Fax: (+49) 231-755-3797Search for more papers by this authorPablo J. Sanz Miguel Dr., Pablo J. Sanz Miguel Dr. Fakultät Chemie, Technische Universität Dortmund, 44221 Dortmund (Germany), Fax: (+49) 231-755-3797Search for more papers by this authorBernhard Lippert Prof. Dr., Bernhard Lippert Prof. Dr. [email protected] Fakultät Chemie, Technische Universität Dortmund, 44221 Dortmund (Germany), Fax: (+49) 231-755-3797Search for more papers by this authorRamon Vilar Dr., Ramon Vilar Dr. [email protected] Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ (UK), Fax: (+44) 2075-941139Search for more papers by this author First published: 16 March 2010 https://doi.org/10.1002/chem.200903501Citations: 24Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract A golden quadruplex DNA: A new gold(III) pyrazolylpyridine complex has been synthesised and structurally characterised. The complex displays π–π interactions in the solid state. The DNA binding properties of the complex have been studied by fluorescent intercalator displacement assay, surface plasmon resonance and circular dichroism. These have shown that the complex interacts strongly with quadruplex DNA, in particular with c-myc. CD spectroscopy has also shown the ability of the complex to template the formation of a quadruplex structure from a singly stranded sequence of telomeric DNA (see picture for a qualitative docking of the complex on top of a quadruplex DNA structure). Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description chem_200903501_sm_miscellaneous_information.pdf432.1 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume16, Issue12March 22, 2010Pages 3613-3616 RelatedInformation