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Mortality, cardiac vagal control and physical training — what's the link?

2002; Wiley; Volume: 87; Issue: 4 Linguagem: Inglês

10.1111/j.1469-445x.2002.tb00055.x

1469-445X

Ashesh N. Buch, John H. Coote, Jonathan N. Townend,

Cardiovascular Effects of Exercise

Experimental PhysiologyVolume 87, Issue 4 p. 423-435 Free Access Mortality, cardiac vagal control and physical training — what's the link? Ashesh N. Buch, Corresponding Author Ashesh N. Buch Department of Cardiovascular Medicine, University of Birmingham[email protected]Search for more papers by this authorJohn H. Coote, John H. Coote Department of Physiology, Medical School, University of Birmingham, UKSearch for more papers by this authorJohn N. Townend, John N. Townend Department of Cardiovascular Medicine, University of BirminghamSearch for more papers by this author Ashesh N. Buch, Corresponding Author Ashesh N. Buch Department of Cardiovascular Medicine, University of Birmingham[email protected]Search for more papers by this authorJohn H. Coote, John H. Coote Department of Physiology, Medical School, University of Birmingham, UKSearch for more papers by this authorJohn N. Townend, John N. Townend Department of Cardiovascular Medicine, University of BirminghamSearch for more papers by this author First published: 04 November 2010 https://doi.org/10.1111/j.1469-445X.2002.tb00055.xCitations: 97AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Adamopoulos, S., Ponikowski, P., Cerquetani, E., Piepoli, M., Rosano, G., Sleight, P. & Coats, A. J. (1995). Circadian pattern of heart rate variability in chronic heart failure patients. Effects of physical training. European Heart Journal 16, 1308–1310. Al-Ani, M., Munir, S. M., White, M., Townend, J. & Coote, J. H. (1996). Changes in R-R variability before and after endurance training measured by power spectral analysis and by the effect of isometric muscle contraction. European Journal of Applied Physiology and Occupational Physiology 74, 397–403. Amano, M., Kanda, T., Ue, H. & Moritani, T. (2001). Exercise training and autonomic nervous system activity in obese individuals. Intensive training and cardiac autonomic control in high level athletes. Medicine and Science in Sports and Exercise 33, 1287–1291. Anonymous (1996). Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93, 1043–1065. Aubert, A. E., Beckers, F. & Ramaekers, D. (2001). Short-term heart rate variability in young athletes. Journal of Cardiology 1, 85–88. Balligand, J. L., Kelly, R. A., Marsden, P. A., Smith, T. W. & Michel, T. (1993). Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proceedings of the National Academy of Sciences of the USA 90, 347–351. Balligand, J. L., Kobzik, L., Han, X., Kaye, D. M., Belhassen, L., O'Hara, D. S., Kelly, R. A., Smith, T. W. & Michel, T. (1995). Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. Journal of Biological Chemistry 270, 14582–14586. Barney, J. A., Ebert, T. J., Groban, L., Farrell, P. A., Hughes, C. V. & Smith, J. J. (1988). Carotid baroreflex responsiveness in high-fit and sedentary young men. Journal of Applied Physiology 65, 2190–2194. Belardinelli, R., Georgiou, D., Cianci, G. & Purcaro, A. (1999). Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation 99, 1173–1182. Berlin, J. A. & Colditz, G. A. (1990). A meta-analysis of physical activity in the prevention of coronary heart disease. American Journal of Epidemioiology 132, 612–628. Bonaduce, D., Petretta, M., Cavallaro, V., Apicella, C., Ianniciello, A., Romano, M., Breglio, R. & Marciano, F. (1998). Intensive training and cardiac autonomic control in high level athletes. Medicine and Science in Sports and Exercise 30, 691–696. Borst, C. & Karemaker, J. M. (1983). Time delays in the human baroreceptor reflex. Journal of the Autonomic Nervous System 9, 399–409. Bolter, C. P., Hughson, R. L. & Critz, J. B. (1973). Intrinsic rate and cholinergic sensitivity of isolated atria from trained and sedentary rats. Proceeding of the Society of Experimental Biology and Medicine 114, 364–367. Boutcher, S. H. & Stein, P. (1995). Association between heart rate variability and training response in sedentary middle-aged men. European Journal of Applied Physiology and Occupational Physiology 70, 75–80. Bowman, A. J., Clayton, R. H., Murray, A., Reed, J. W., Subhan, M. M. & Ford, G. A. (1997). Effects of aerobic exercise training and yoga on the baroreflex in healthy elderly persons. European Journal of Clinical Investigation 27, 443–449. Casado, M. A., Sevilla, M. A., Alonso, M. J., Marin, J. & Salaices, M. (1994). Muscarinic receptors involved in modulation of norepinephrine release and vasodilatation in guinea pig carotid arteries. Journal of Pharmacology and Experimental Therapeutics 271, 1638–1646. Cerati, D., Nador, F., Maestri, R., Mantica, M., Binda, A., Perlini, S. & Vanoli, E. (1997). Influence of residual ischaemia on heart rate variability after myocardial infarction. European Heart Journal 18, 78–83. Cerati, D. & Schwartz, P. J. (1991). Single cardiac vagal fiber activity, acute myocardial ischemia, and risk for sudden death. Circulation Research 69, 1389–1401. Chen, R. Y., Fan, F. C., Schuessler, G. B. & Chien, S. (1982). Baroreflex control of heart rate in humans during nitroprusside-induced hypotension. American Journal of Physiology 243, R18–24. Chowdhary, S., Nuttall, S. L., Coote, J. H. & Townend, J. N. (2002). l-Arginine augments cardiac vagal control in healthy human subjects. Hypertension 39, 51–56. Chowdhary, S., Vaile, J. C., Fletcher, J., Ross, H. F., Coote, J. H. & Townend, J. N. (2000). Nitric oxide and cardiac autonomic control in humans. Hypertension 36, 264–269. Coats, A. J., Adamopoulos, S., Radaelli, A., McCance, A., Meyer, T. E., Bernardi, L., Solda, P. L., Davey, P., Ormerod, O. & Forfar, C. (1992). Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function. Circulation 85, 2119–2131. Communal, C., Singh, K., Sawyer, D. B. & Colucci, W. S. (1999). Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis: role of a pertussis toxin-sensitive G protein. Circulation 100, 2210–2212. Conlon, K., Collins, T. & Kidd, C. (1996). Modulation of vagal actions on heart rate produced by inhibition of nitric oxide synthase in the anaesthetized ferret. Experimental Physiology 81, 547–550. Conlon, K., Collins, T. & Kidd, C. (1998). The role of nitric oxide in the control by the vagal nerves of the heart of the ferret. Experimental Physiology 83, 469–480. Conlon, K. & Kidd, C. (1999). Neuronal nitric oxide facilitates vagal chronotropic and dromotropic actions on the heart. Journal of the Autonomic Nervous System 75, 136–146. Convertino, V. A., Keil, L. C., Bernauer, E. M. & Greenleaf, J. E. (1981). Plasma volume, osmolality, vasopressin, and renin activity during graded exercise in man. Journal of Applied Physiology 50, 123–128. Corr, P. B. & Gillis, R. A. (1974). Role of the vagus nerves in the cardiovascular changes induced by coronary occlusion. Circulation 49, 86–97. Davy, K. P., Desouza, C. A., Jones, P. P. & Seals, D. R. (1998). Elevated heart rate variability in physically active young and older adult women. Clinical Science 94, 579–584. Davy, K. P., Willis, W. L. & Seals, D. R. (1997). Influence of exercise training on heart rate variability in post-menopausal women with elevated arterial blood pressure. Clinical Physiology 17, 31–40. De Ferrari, G. M., Vanoli, E., Curcuruto, P., Tommasini, G. & Schwartz, P. J. (1992). Prevention of life-threatening arrhythmias by pharmacologic stimulation of the muscarinic receptors with oxotremorine. American Heart Journal 124, 883–890. De Meersman, R. E. (1992). Respiratory sinus arrhythmia alteration following training in endurance athletes. European Journal of Applied Physiology and Occupational Physiology 64, 434–436. De, M. R. E. (1993). Heart rate variability and aerobic fitness. American Heart Journal 125, 726–731. Deligiannis, A., Kouidi, E. & Tourkantonis, A. (1999). Effects of physical training on heart rate variability in patients on hemodialysis. American Journal of Cardiology 84, 197–202. Dixon, E. M., Kamath, M. V., McCartney, N. & Fallen, E. L. (1992). Neural regulation of heart rate variability in endurance athletes and sedentary controls. Cardiovascular Research 26, 713–719. Dun, N. J., Dun, S. L. & Forstermann, U. (1994). Nitric oxide synthase immunoreactivity in rat pontine medullary neurons. Neuroscience 59, 429–445. Duru, F., Candinas, R., Dziekan, G., Goebbels, U., Myers, J. & Dubach, P. (2000). Effect of exercise training on heart rate variability in patients with new-onset left ventricular dysfunction after myocardial infarction. American Heart Journal 140, 157–161. Eckberg, D. L. (1983). Human sinus arrhythmia as an index of vagal cardiac outflow. Journal of Applied Physiology 54, 961–966. Eckberg, D. L., Cavanaugh, M. S., Mark, A. L. & Abboud, F. M. (1975). A simplified neck suction device for activation of carotid baroreceptors. Journal of Laboratory and Clinical Medicine 85, 167–173. Ellenbogen, K. A., Mohanty, P. K., Szentpetery, S. & Thames, M. D. (1989). Arterial baroreflex abnormalities in heart failure. Reversal after orthotopic cardiac transplantation. Circulation 79, 51–58. Fagard, R., Grauwels, R., Groeseneken, D., Lijnen, P., Staessen, J., Vanhees, L. & Amery, A. (1985). Plasma levels of renin, angiotensin II, and 6-ketoprostaglandin F1 alpha in endurance athletes. Journal of Applied Physiology 59, 947–952. Fiocchi, R., Fagard, R., Staessen, J., Vanhees, L. & Amery, A. (1985). Relationship between carotid baroreflex sensitivity, physical fitness and activity in cyclists. Journal of Hypertension, Supplement 3. Furlan, R., Piazza, S., Dell'orto, S., Gentile, E., Cerutti, S., Pagani, M. & Malliani, A. (1993). Early and late effects of exercise and athletic training on neural mechanisms controlling heart rate. Cardiovascular Research 27, 482–488. Gai, W. P., Messenger, J. P., Yu, Y. H., Gieroba, Z. J. & Blessing, W. W. (1995). Nitric oxide-synthesising neurons in the central subnucleus of the nucleus tractus solitarius provide a major innervation of the rostral nucleus ambiguus in the rabbit. Journal of Comparative Neurology 357, 348–361. Geyssant, A., Geelen, G., Denis, C., Allevard, A. M., Vincent, M., Jarsaillon, E., Bizollon, C. A., Lacour, J. R. & Gharib, C. (1981). Plasma vasopressin, renin activity, and aldosterone: effect of exercise and training. European Journal of Applied Physiology and Occupational Physiology 46, 21–30. Gharib, C., Vincent, M., Annat, G., Allevard, A. M., Geelen, G., Geyssant, A., Eclache, J. P., Lacour, R. & Bizollon, C. A. (1981). [Plasma renin activity (PRA) and aldosterone (PA) during submaximal exercise. Effect of training.] (Author's translation). Journal of Physiology (Paris) 77, 911–914. Goldberger, J. J., Kim, Y. H., Ahmed, M. W. & Kadish, A. H. (1996). Effect of graded increases in parasympathetic tone on heart rate variability. Journal of Cardiovascular Electrophysiology 7, 594–602. Goldsmith, R. L., Bigger, J. T. Jr, Steinman, R. C. & Fleiss, J. L. (1992). Comparison of 24-hour parasympathetic activity in endurance-trained and untrained young men. Journal of the American College of Cardiology 20, 552–558. Greenleaf, J. E., Sciaraffa, D., Shvartz, E., Keil, L. C. & Brock, P. J. (1981). Exercise training hypotension: implications for plasma volume, renin, and vasopressin. Journal of Applied Physiology 51, 298–305. Gregoire, J., Tuck, S., Yamamoto, Y. & Hughson, R. L. (1996). Heart rate variability at rest and exercise: influence of age, gender, and physical training. Canadian Journal of Applied Physiology 21, 455–470. Guo, X. H., Yi, G., Batchvarov, V., Gallagher, M. M. & Malik, M. (1999). Effect of moderate physical exercise on noninvasive cardiac autonomic tests in healthy volunteers. International Journal of Cardiology 69, 155–168. Hakim, A. A., Petrovitch, H., Burchfiel, C. M., Ross, G. W., Rodriguez, B. L., White, L. R., Yano, K., Curb, J. D. & Abbott, R. D. (1998). Effects of walking on mortality among nonsmoking retired men. New England Journal of Medicine 338, 94–99. Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N. & Schuler, G. (2000). Effect of exercise on coronary endothelial function in patients with coronary artery disease. New England Journal of Medicine 342, 454–460. Hedelin, R., Bjerle, P. & Henriksson-Larsen, K. (2001). Heart rate variability in athletes: relationship with central and peripheral performance. Medicine and Science in Sports and Exercise 33, 1394–1398. Hedelin, R., Wiklund, U., Bjerle, P. & Henriksson-Larsen, K. (2000). Pre- and post-season heart rate variability in adolescent cross-country skiers. Scandinavian Journal of Medicine and Science in Sports 10, 298–303. Herring, N., Golding, S. & Paterson, D. J. (2000). Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atria. Journal of Molecular and Cellular Cardiology 32, 1795–1804. Herrlich, H. C., Raab, W. & Gigee, W. (1960). Influence of muscular training and the catecholamines on cardiac acetylcholine and cholinesterase. Archives Internationales Pharmacodynamie 129, 201. Hespel, P., Lijnen, P., Van Hoof, R., Fagard, R., Goossens, W., Lissens, W., Moerman, E. & Amery, A. (1988). Effects of physical endurance training on the plasma renin-angiotensin-aldosterone system in normal man. Journal of Endocrinology 116, 443–449. Hull, S. S., Vanoli, E., Adamson, P. B., Verrier, R. L., Foreman, R. D. & Schwartz, P. J. (1994). Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation 89, 548–552. Iellamo, F., Legramante, J. M., Massaro, M., Raimondi, G. & Galante, A. (2000). Effects of a residential exercise training on baroreflex sensitivity and heart rate variability in patients with coronary artery disease: A randomized, controlled study. Circulation 102, 2588–2592. Ikaheimo, M. J., Palatsi, I. J. & Takkunen, J. T. (1979). Noninvasive evaluation of the athletic heart: sprinters versus endurance runners. American Journal of Cardiology 44, 24–30. Jennings, G., Nelson, L., Nestel, P., Esler, M., Korner, P., Burton, D. & Bazelmans, J. (1986). The effects of changes in physical activity on major cardiovascular risk factors, hemodynamics, sympathetic function, and glucose utilization in man: a controlled study of four levels of activity. Circulation 73, 30–40. Jensen-Urstad, K., Saltin, B., Ericson, M., Storck, N. & Jensen-Urstad, M. (1997). Pronounced resting bradycardia in male elite runners is associated with high heart rate variability. Scandinavian Journal of Medicine and Science in Sports 7, 274–278. Jumrussirikul, P., Dinerman, J., Dawson, T. M., Dawson, V. L., Ekelund, U., Georgakopoulos, D., Schramm, L. P., Calkins, H., Snyder, S. H., Hare, J. M. & Berger, R. D. (1998). Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice. Journal of Clinical Investigation 102, 1279–1285. Kallio, V., Hamalainen, H., Hakkila, J. & Luurila, O. J. (1979). Reduction in sudden deaths by a multifactorial intervention programme after acute myocardial infarction. Lancet 2, 1091–1094. Kannel, W. B. & Sorlie, P. (1979). Some health benefits of physical activity. The Framingham Study. Archives of Internal Medicine 139, 857–861. Kao, W. & Jessup, M. (1994). Exercise testing and exercise training in patients with congestive heart failure. [Review - 20 refs]. Journal of Heart and Lung Transplantation 13, S117–121. Katona, P. G., McLean, M., Dighton, D. H. & Guz, A. (1982). Sympathetic and parasympathetic cardiac control in athletes and nonathletes at rest. Journal of Applied Physiology 52, 1652–1657. Kent, K. M., Smith, E. R., Redwood, D. R. & Epstein, S. E. (1973). Electrical stability of acutely ischemic myocardium. Influences of heart rate and vagal stimulation. Circulation 47, 291–298. Keteyian, S. J., Brawner, C. A. & Schairer, J. R. (1997). Exercise testing and training of patients with heart failure due to left ventricular systolic dysfunction. [Review - 58 refs]. Journal of Cardiopulmonary Rehabilitation 17, 19–28. Klilavuori, K., Toivonen, L., Naveri, H. & Leinonen, H. (1995). Reversal of autonomic derangements by physical training in chronic heart failure assessed by heart rate variability. European Heart Journal 16, 490–495. Kiyonaga, A., Arakawa, K., Tanaka, H. & Shindo, M. (1985). Blood pressure and hormonal responses to aerobic exercise. Hypertension 7, 125–131. Klimaschewski, L., Kummer, W., Mayer, B., Couraud, J. Y., Preissler, U., Philippin, B. & Heym, C. (1992). Nitric oxide synthase in cardiac nerve fibers and neurons of rat and guinea pig heart. Circulation Research 71, 1533–1537. Koch, M., Douard, H. & Broustet, J. P. (1992). The benefit of graded physical exercise in chronic heart failure. Chest 101, 231S–235S. Kunze, D. L. (1972). Reflex discharge patterns of cardiac vagal efferent fibres. Journal of Physiology 222, 1–15. La Rovere, M. T., Bigger, J. T. Jr, Marcus, F. I., Mortara, A. & Schwartz, P. J. (1998). Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (autonomic tone and reflexes after myocardial infarction) investigators. Lancet 351, 478–484. Lawrence, A. J. (1997). Nitric oxide as a modulator of medullary pathways. Clinical and Experimental Pharmacology and Physiology 24, 760–763. Leitch, J. W., Newling, R. P., Basta, M., Inder, K., Dear, K. & Fletcher, P. J. (1997). Randomized trial of a hospital-based exercise training program after acute myocardial infarction: cardiac autonomic effects. Journal of the American College of Cardiology 29, 1263–1268. Levine, B. D., Buckey, J. C., Fritsch, J. M., Yancy, C. W. Jr, Watenpaugh, D. E., Snell, P. G., Lane, L. D., Eckberg, D. L. & Blomqvist, C. G. (1991). Physical fitness and cardiovascular regulation: mechanisms of orthostatic intolerance. Journal of Applied Physiology 70, 112–122. Levy, W. C., Cerqueira, M. D., Harp, G. D., Johannessen, K. A., Abrass, I. B., Schwartz, R. S. & Stratton, J. R. (1998). Effect of endurance exercise training on heart rate variability at rest in healthy young and older men. American Journal of Cardiology 82, 1236–1241. Lewis, M. E., Al-Khalidi, A. H., Bonser, R. S., Clutton-Brock, T., Morton, D., Paterson, D., Townend, J. N. & Coote, J. H. (2001). Vagus nerve stimulation decreases left ventricular contractility in vivo in the human and pig heart. Journal of Physiology 534, 547–552. Lewis, S. F., Nylander, E., Gad, P. & Areskog, N. H. (1980). Non-autonomic component in bradycardia of endurance trained men at rest and during exercise. Acta Physiologica Scandinavica 109, 297–305. Liinen, P., Hespel, P., Van Oppens, S., Fiocchi, R., Goossens, W., Vanden Eynde, E. & Amery, A. (1986). Erythrocyte 2,3-diphosphoglycerate and serum enzyme concentrations in trained and sedentary men. Medicine and Science in Sports and Exercise 18, 174–179. Loffelholz, K. & Muscholl, E. (1969). A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation. Naunyn-Schmiedeberg's Archives of Pharmacology 265, 1–15. Loimaala, A., Huikuri, H., Oja, P., Pasanen, M. & Vuori, I. (2000). Controlled 5-mo aerobic training improves heart rate but not heart rate variability or baroreflex sensitivity. Journal of Applied Physiology 89, 1825–1829. McDonald, M. P., Sanfilippo, A. J. & Savard, G. K. (1993). Baroreflex function and cardiac structure with moderate endurance training in normotensive men. Journal of Applied Physiology 74, 2469–2477. Maciel, B. C., Gallo, J. L., Marin, N. J. A., Lima, F. E. C., Terra, F. J. & Manco, J. C. (1985). Parasympathetic contribution to bradycardia induced by endurance training in man. Cardiovascular Research 19, 642–648. Malfatto, G., Facchini, M., Bragato, R., Branzi, G., Sala, L. & Leonetti, G. (1996). Short and long term effects of exercise training on the tonic autonomic modulation of heart rate variability after myocardial infarction. European Heart Journal 17, 532–538. Malik, M. & Camm, A. J. (1993). Components of heart rate variability-what they really mean and what we really measure. American Journal of Cardiology 72, 821–822. Mann, D. L., Kent, R. L., Parsons, B. & Cooper, G. T. (1992). Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 85, 790–804. Manson, J. E., Hu, F. B., Rich-Edwards, J. W., Colditz, G. A., Stampfer, M. J., Willett, W. C., Speizer, F. E. & Hennekens, C. H. (1999). A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. New England Journal of Medicine 341, 650–658. Maqbool, A., Batten, T. F. & McWilliam, P. N. (1995). Co-localization of neurotransmitter immunoreactivities in putative nitric oxide synthesizing neurones of the cat brain stem. Journal of Chemical Neuroanatomy 8, 191–206. Markos, F., Snow, H. M., Kidd, C. & Conlon, K. (2001). Inhibition of neuronal nitric oxide reduces heart rate variability in the anaesthetised dog. Experimental Physiology 86, 539–541. Mazzuero, G., Lanfranchi, P., Colombo, R., Giannuzzi, P. & Giordano, A. (1992). Long term adaptation of 24-h heart rate variability after myocardial infarction. The EAMI Study Group. Exercise Training in Anterior Myocardial Infarction. Chest 101, 304S–308S. Melanson, E. L. & Freedson, P. S. (2001). The effect of endurance training on resting heart rate variability in sedentary adult males. European Journal of Applied Physiology 85, 442–449. Mohan, R. M., Choate, J. K., Golding, S., Herring, N., Casadei, B. & Paterson, D. J. (2000). Peripheral pre-synaptic pathway reduces the heart rate response to sympathetic activation following exercise training: role of NO. Cardiovascular Research 47, 90–98. Monahan, K. D., Dinenno, F. A., Tanaka, H., Clevenger, C. M., Desouza, C. A. & Seals, D. R. (2000). Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men. Journal of Physiology 1, 263–271. Monahan, K. D., Tanaka, H., Dinenno, F. A. & Seals, D. R. (2001). Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity. Circulation 104, 1627–1632. Mortara, A., Sleight, P., Pinna, G. D., Maestri, R., Prpa, A., La, R. M. T., Cobelli, F. & Tavazzi, L. (1997). Abnormal awake respiratory patterns are common in chronic heart failure and may prevent evaluation of autonomic tone by measures of heart rate variability (erratum appears in Circulation 96, 4118 (1997)). Circulation 96, 246–252. Nelson, L., Jennings, G. L., Esler, M. D. & Korner, P. I. (1986). Effect of changing levels of physical activity on blood-pressure and haemodynamics in essential hypertension. Lancet 2, 473–476. Nolan, J., Batin, P. D., Andrews, R., Lindsay, S. J., Brooksby, P., Mullen, M., Baig, W., Flapan, A. D., Cowley, A., Prescott, R. J., Neilson, J. M. & Fox, K. A. (1998). Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation 98, 1510–1516. O'Connor, G. T., Buring, J. E., Yusuf, S., Goldhaber, S. Z., Olmstead, E. M., Paffenbarger, R. S. Jr & Hennekens, C. H. (1989). An overview of randomized trials of rehabilitation with exercise after myocardial infarction. Circulation 80, 234–244. Osterziel, K. J., Hanlein, D., Willenbrock, R., Eichhorn, C., Luft, F. & Dietz, R. (1995). Baroreflex sensitivity and cardiovascular mortality in patients with mild to moderate heart failure. British Heart Journal 73, 517–522. Oya, M., Itoh, H., Kato, K., Tanabe, K. & Murayama, M. (1999). Effects of exercise training on the recovery of the autonomic nervous system and exercise capacity after acute myocardial infarction. Japanese Circulation Journal 63, 843–848. Paffenbarger, R. S., Hyde, R. T., Wing, A. L., Lee, I.-M., Jung, D. L. & Kampert, J. B. (1993). The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. New England Journal of Medicine 328, 538–545. Pagani, M., Somers, V., Furlan, R., Dell'orto, S., Conway, J., Baselli, G., Cerutti, S., Sleight, P. & Malliani, A. (1988). Changes in autonomic regulation induced by physical training in mild hypertension. Hypertension 12, 600–610. Parati, G., Di, R. M., Bertinieri, G., Pomidossi, G., Casadei, R., Groppelli, A., Pedotti, A., Zanchetti, A. & Mancia, G. (1988). Evaluation of the baroreceptor-heart rate reflex by 24-hour intraarterial blood pressure monitoring in humans. Hypertension 12, 214–222. Pardo, Y., Merz, C. N., Velasquez, I., Paul-Labrador, M., Agarwala, A. & Peter, C. T. (2000). Exercise conditioning and heart rate variability: evidence of a threshold effect. Clinical Cardiology 23, 615–620. Patel, K. P., Zhang, K., Zucker, I. H. & Krukoff, T. L. (1996). Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure. Brain Research 734, 109–115. Pichot, V., Roche, F., Gaspoz, J. M., Enjolras, F., Antoniadis, A., Minini, P., Costes, F., Busso, T., Lacour, J. R. & Barthelemy, J. C. (2000). Relation between heart rate variability and training load in middle-distance runners. Medicine and Science in Sports and Exercise 32, 1729–1736. Pigozzi, F., Alabiso, A., Parisi, A., Di, S. V., Di, L. L., Spataro, A. & Iellamo, F. (2001). Effects of aerobic exercise training on 24 h profile of heart rate variability in female athletes. Journal of Sports Medicine and Physical Fitness 41, 101–107. Portier, H., Louisy, F., Laude, D., Berthelot & Guezennec, C. Y. (2001). Intense endurance training on heart rate and blood pressure variability in runners. Medicine and Science in Sports and Exercise 33, 1120–1125. Radaelli, A., Coats, A. J., Leuzzi, S., Piepoli, M., Meyer, T. E., Calciati, A., Finardi, G., Bernardi, L. & Sleight, P. (1996). Physical training enhances sympathetic and parasympathetic control of heart rate and peripheral vessels in chronic heart failure. Clinical Science 91, 92–94. Reiling, M. J. & Seals, D. R. (1988). Respiratory sinus arrhythmia and carotid baroreflex control of heart rate in endurance athletes and untrained controls. Clinical Physiology 8, 511–519. Sacknoff, D. M., Gleim, G. W., Stachenfeld, N. & Coplan, N. L. (1994). Effect of athletic training on heart rate variability. American Heart Journal 127, 1275–1278. Sandvik, L., Erikssen, J., Thaulow, E., Erikssen, G., Mundal, R. & Rodahl, K. (1993). Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men. New England Journal of Medicine 328, 533–537. Schuit, A. J., Van, A. L. G., Verheij, T. C., Rijneke, R. D., Maan, A. C., Swenne, C. A. & Schouten, E. G. (1999). Exercise training and heart rate variability in older people. Medicine and Science in Sports and Exercise 31, 816–821. Schwartz, P. J., Vanoli, E., Stramba-Badiale, M., De, F. G. M., Billman, G. E. & Foreman, R. D. (1988). Autonomic mechanisms and sudden death. New insights from analysis of baroreceptor reflexes in conscious dogs with and without a myocardial infarction. Circulation 78, 969–979. Seals, D. R. & Chase, P. B. (1989). Influence of physical training on heart rate variability and baroreflex circulatory control. Journal of Applied Physiology 66, 1886–1895. Sheldahl, L. M., Ebert, T. J., Cox, B. & Tristani, F. E. (1994). Effect of aerobic training on baroreflex regulation of cardiac and sympathetic function. Journal of Applied Physiology 76, 158–165. Shin, K., Minamitani, H., Onishi, S., Yamazaki, H. & Lee, M. (1995). The power spectral analysis of heart rate variability in athletes during dynamic exercise — Part I. Clinical Cardiology 18, 583–586. Shin, K., Minamitani, H., Onishi, S., Yamazaki, H. & Lee, M. (1997). Autonomic differences between athletes and nonathletes: spectral analysis approach. Medicine and Science in Sports and Exercise 29, 1482–1490. Skipka, W., Boning, D., Deck, K. A., Kulpmann, W. R. & Meurer, K. A. (1979). Reduced aldosterone and sodium excretion in endurance-trained athletes before and during immersion. European Journal of Applied Physiology and Occupational Physiology 42, 255–261. Smith, S. A., Querry, R. G., Fadel, P. J., Welch-O'Connor, R. M., Olivencia-Yurvati, A., Shi, X. & Raven, P. B. (2000). Differential baroreflex control of heart rate in sedentary and aerobically fit individuals. Medicine and Science in Sports and Exercise 32, 1419–1430. Smith, S. A., Stallard, T. J., Salih, M. M. & Littler, W. A. (1987). Can sinoaortic baroreceptor heart rate reflex sensitivity be determined from phase IV of the Valsalva manoeuvre? Cardiovascular Research 21, 422–427. Smyth, H. S., Sleight, P. & Pickering, G. W. (1969). Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity. Circulation Research 24, 109–121. Somers, V. K., Conway, J., Johnston, J. & Sleight, P. (1991). Effects of endurance training on baroreflex sensitivity and blood pressure in borderline hypertension. Lancet 337, 1363–1368. Squires, R. W., Lavie, C. J., Brandt, T. R., Gau, G. T. & Bailey, K. R. (1987). Cardiac rehabilitation in patients with severe ischemic left ventricular dysfunction. Mayo Clinic Proceedings 62, 997–1002. Stahle, A., Nordlander, R. & Bergfeldt, L. (1999). Aerobic group training improves exercise capacity and heart rate variability in elderly patients with a recent coronary event. A randomized controlled study. European Heart Journal 20, 1638–1646. Stein, P. K., Ehsani, A. A., Domitrovich, P. P., Kleiger, R. E. & Rottman, J. N. (1999). Effect of exercise training on heart rate variability in healthy older adults. American Heart Journal 138, 567–576. Sullivan, M. J. & Hawthorne, M. H. (1996). Nonpharmacologic interventions in the treatment of heart failure. [Review - 44 refs]. Journal of Cardiovascular Nursing 10, 47–57. Thames, M. D. & Kontos, H. A. (1970). Mechanisms of baroreceptor-induced changes in heart rate. American Journal of Physiology 218, 251–256. Travagli, R. A. & Gillis, R. A. (1994). Nitric oxide-mediated excitatory effect on neurons of dorsal motor nucleus of vagus. American Journal of Physiology 266, G154–160. Tsuji, H., Larson, M. G., Venditti, F. J. Jr, Manders, E. S., Evans, J. C., Feldman, C. L. & Levy, D. (1996). Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 94, 2850–2855. Tsuji, H., Venditti, F. J. Jr, Manders, E. S., Evans, J. C., Larson, M. G., Feldman, C. L. & Levy, D. (1994). Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation 90, 878–883. Tygesen, H., Wettervik, C. & Wennerblom, B. (2001). Intensive home-based exercise training in cardiac rehabilitation increases exercise capacity and heart rate variability. International Journal of Cardiology 79, 175–182. Uusitalo, A. L., Uusitalo, A. J. & Rusko, H. K. (1998). Endurance training, overtraining and baroreflex sensitivity in female athletes. Clinical Physiology 18, 510–520. Vanhees, L., Fagard, R., Lijnen, P., Moerman, E., De Geest, H. & Amery, A. (1984). Influence of physical training on blood pressure, plasma renin, angiotensin and catecholamines in patients with ischaemic heart disease. European Journal of Applied Physiology and Occupational Physiology 53, 219–224. Vanhoutte, P. M. (1974). Inhibition by acetylcholine of adrenergic neurotransmission in vascular smooth muscle. Circulation Research 34, 317–326. Vanoli, E., De, F. G. M., Stramba-Badiale, M., Hull, S. S., Foreman, R. D. & Schwartz, P. J. (1991). Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction. Circulation Research 68, 1471–1481. Watanabe, A. M., McConnaughey, M. M., Strawbridge, R. A., Fleming, J. W., Jones, L. R. & Besch, H. R. Jr (1978). Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines. Journal of Biological Chemistry 253, 4833–4836. Williams, M. A., Fleg, J. L., Ades, P. A., Chaitman, B. R., Miller, N. H., Mohiuddin, S. M., Ockene, I. S., Taylor, C. B. & Wenger, N. K. (2002). Secondary prevention of coronary heart disease in the elderly (with emphasis on patients > 75 years of age): An American Heart Association Scientific Statement from the Council on Clinical Cardiology Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention. Circulation 105, 1735–1743. Woodman, C. R., Muller, J. M., Laughlin, M. H. & Price, E. M. (1997). Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs. American Journal of Physiology 273, H2575–2579. Yamamoto, K., Miyachi, M., Saitoh, T., Yoshioka, A. & Onodera, S. (2001). Effects of endurance training on resting and post-exercise cardiac autonomic control. Medicine and Science in Sports and Exercise 33, 1496–1502. Zhang, K., Li, Y.-F. & Patel, K. P. (2001). Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure. American Journal of Physiology — Heart and Circulatory Physiology 281, H995–1004. Zhang, K., Zucker, I. H. & Patel, K. P. (1998). Altered number of diaphorase (NOS) positive neurons in the hypothalamus of rats with heart failure. Brain Research 786, 219–225. Zheng, H., Li, Y.-F. & Patel, K. P. (2002). Exercise training improves endogenous nitric oxide mechanisms within the PVN involved in regulating renal sympathetic nerve activity in rats with heart failure. FASEB Journal 16, A661. Citing Literature Volume87, Issue4July 2002Pages 423-435 This article also appears in:John H. Coote commemorative virtual issueJohn Coote Commemoration ReferencesRelatedInformation