Expression of Cardiac Troponin T in Skeletal Muscle
1998; American Association for Clinical Chemistry; Volume: 44; Issue: 2 Linguagem: Inglês
10.1093/clinchem/44.2.358
ISSN1530-8561
AutoresChristlieb Haller, Hugo A. Katus,
Tópico(s)Cardiovascular Effects of Exercise
ResumoIn their report earlier this year, McLaurin et al. reproduced the finding of increased cardiac troponin T (cTnT) concentrations in dialysis patients [ 1] . Using the first-generation cTnT assay, they observed an increased serum concentration of cTnT in 17 of 24 patients. The prevalence of an increased cTnT concentration in the blood of dialysis patients was somewhat lower when the second-generation cTnT assay was used, but higher than the prevalence of an increased concentration of cardiac troponin I (cTnI). Because none of the patients had clinically apparent cardiac ischemia (although most had hypertension or other cardiac risk factors, and 2 had echocardiographically documented hypertensive heart disease), the increased cTnT concentrations were interpreted as “false positive.” The authors suggested this might be related to the extracardiac expression of cTnT, which they believed to have demonstrated in skeletal muscle biopsies from 4 … bAuthor for correspondence. E-mail fred.apple{at}co.hennepin.mn.us
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