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BIBTEX RIS

In vitro antifungal activity of fatty acid methyl esters of the seeds of Annona cornifolia A.St.-Hil. (Annonaceae) against pathogenic fungus Paracoccidioides brasiliensis

2011; Brazilian Society of Tropical Medicine; Volume: 44; Issue: 6 Linguagem: Inglês

10.1590/s0037-86822011000600024

ISSN

1678-9849

Autores

Luciana Alves Rodrigues dos Santos Lima, Susana Johann, Patrícia Silva Cisalpino, Lúcia Pinheiro Santos Pimenta, Maria Amélia D. Boaventura,

Tópico(s)

Cocoa and Sweet Potato Agronomy

Resumo

INTRODUCTION: Fatty acids are abundant in vegetable oils. They are known to have antibacterial and antifungal properties. METHODS: Antifungal susceptibility was evaluated by broth microdilution assay following CLSI (formerly the NCCLS) guidelines against 16 fungal strains of clinical interest. RESULTS: In this work, fatty acid methyl esters (FAME) was able to inhibit 12 clinical strains of the pathogenic fungus Paracoccidioides brasiliensis and were also active in the bioautographic assay against Cladosporium sphaerospermum. CONCLUSIONS: FAME was a more potent antifungal than trimethoprim-sulfamethoxazole against P. brasiliensis under the experimental conditions tested.

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