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Properties of nanoparticles prepared from NdFeB-based compound for magnetic hyperthermia application

2012; IOP Publishing; Volume: 23; Issue: 17 Linguagem: Inglês

10.1088/0957-4484/23/17/175704

1361-6528

E.A. Périgo, S. C. Silva, Edésia Martins Barros de Sousa, Anderson Santos De Freitas, Renato Cohen, L.C.C.M. Nagamine, Hidetoshi Takiishi, Fernando José Gomes Landgraf,

Advanced MRI Techniques and Applications

Nanoparticles were prepared from a NdFeB-based alloy using the hydrogen decrepitation process together with high-energy ball milling and tested as heating agent for magnetic hyperthermia. In the milling time range evaluated (up to 10 h), the magnetic moment per mass at H = 1.59 MA m−1 is superior than 70 A m2 kg−1; however, the intrinsic coercivity might be inferior than 20 kA m−1. The material presents both ferromagnetic and superparamagnetic particles constituted by a mixture of phases due to the incomplete disproportionation reaction of Nd2Fe14BHx during milling. Solutions prepared with deionized water and magnetic particles exposed to an AC magnetic field (Hmax ∼ 3.7 kA m−1 and f = 228 kHz) exhibited 26 K ≤ ΔTmax ≤ 44 K with a maximum estimated specific absorption rate (SAR) of 225 W kg−1. For the pure magnetic material milled for the longest period of time (10 h), the SAR was estimated as ∼2500 W kg−1. In vitro tests indicated that the powders have acceptable cytotoxicity over a wide range of concentration (0.1–100 µg ml−1) due to the coating applied during milling.