Spermatogonial stem cells: questions, models and perspectives
2006; Oxford University Press; Volume: 12; Issue: 3 Linguagem: Inglês
10.1093/humupd/dmk001
ISSN1460-2369
AutoresJens Ehmcke, Joachim Wistuba, Stefan Schlatt,
Tópico(s)Pluripotent Stem Cells Research
ResumoThis review looks into the phylogeny of spermatogonial stem cells and describes their basic biological features. We are focusing on species-specific differences of spermatogonial stem cell physiology. We propose revised models for the clonal expansion of spermatogonia and for the potential existence of true stem cells and progenitors in primates but not in rodents. We create a new model for the species-specific arrangements of spermatogenic stages which may depend on the variable clonal expansion patterns. We also provide a brief overview of germ cell transplantation as a powerful tool for basic research and its potential use in a clinical setting.
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