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Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats

2008; Oxford University Press; Volume: 23; Issue: 6 Linguagem: Inglês

10.1093/ndt/gfm861

1460-2385

Ayinuer Adijiang, Shunsuke Goto, S. Uramoto, F. Nishijima, Toshimitsu Niwa,

Muscle and Compartmental Disorders

Background. Stage 5 chronic kidney disease (CKD) is associated with enhanced aortic calcification. The aim of this study was to determine if the administration of indoxyl sulphate (IS), a uraemic toxin, stimulates the progression of aortic calcification.