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Human Immunodeficiency Virus–1 RNA Levels and CD4 Lymphocyte Counts, during Treatment for Active Tuberculosis, in South African Patients

2003; Oxford University Press; Volume: 187; Issue: 12 Linguagem: Inglês

10.1086/375346

1537-6613

Lynn Morris, Desmond J. Martin, Helba Bredell, S. Nyoka, Leonard Sacks, Stella Pendle, Liesl Page‐Shipp, Christopher L. Karp, Timothy R. Sterling, Thomas C. Quinn, Richard E. Chaisson,

Pneumocystis jirovecii pneumonia detection and treatment

During 6 months of treatment, we measured human immunodeficiency virus (HIV)–1 virus loads, CD4 T cell counts, and immune activation markers, in 111 HIV-1–infected patients with active tuberculosis (TB). The median virus load (baseline, 5.58 log10 copies/mL) significantly increased at 1 month (5.71 log10 copies/mL), then returned to near-baseline levels at 3 months (5.40 log10 copies/mL) and at 6 months (5.36 log10 copies/mL). In contrast, the median CD4 counts increased at 1 month (186/mm3), at 3 months (238/mm3), and at 6 months (239/mm3). CD4 counts and virus loads did not change during therapy. Expression of CD38 and HLA-DR remained high throughout treatment, whereas plasma levels of interleukin-6 decreased over time