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BIBTEX RIS

PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes

2014; Oxford University Press; Volume: 42; Issue: W1 Linguagem: Inglês

10.1093/nar/gku397

ISSN

1362-4962

Autores

Alper Baspinar, Engin Cukuroglu, Ruth Nussinov, Özlem Keskin, Attila Gürsoy,

Tópico(s)

Bioinformatics and Genomic Networks

Resumo

The PRISM web server enables fast and accurate prediction of protein–protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism.

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