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Predictors of high vancomycin MIC values among patients with methicillin-resistant Staphylococcus aureus bacteraemia

2008; Oxford University Press; Volume: 62; Issue: 5 Linguagem: Inglês

10.1093/jac/dkn329

1460-2091

Thomas P. Lodise, Chris D. Miller, Jeffrey Graves, A. Evans, Eileen Graffunder, Megan R. Helmecke, Kathleen A. Stellrecht,

Clostridium difficile and Clostridium perfringens research

BackgroundRecent evidence suggests that vancomycin demonstrates reduced activity against methicillin-resistant Staphylococcus aureus (MRSA) infections when vancomycin MIC values are at the high end of the susceptibility range (≥1.5 mg/L). However, scant research exists on factors predictive of high vancomycin MICs (≥1.5 mg/L) among MRSA bacteraemic patients. Empirical therapy decisions would greatly benefit from such information.