A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo
2001; Elsevier BV; Volume: 22; Issue: 3 Linguagem: Inglês
10.1016/s1471-4906(00)01844-5
ISSN1471-4981
AutoresPranab K. Das, R.M.J.G.J. van den Wijngaard, Anna Wańkowicz-Kalińska, I. Caroline Le Poole,
Tópico(s)T-cell and B-cell Immunology
ResumoVitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.
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