Phytochemical screening and evaluation of cytotoxic, antimicrobial and cardiovascular effects of Gomphrena globosa L. (Amaranthaceae)
2011; Academic Journals; Volume: 5; Issue: 10 Linguagem: Inglês
10.5897/jmpr.9001007
ISSN1996-0875
AutoresDaniel Dias Rufino Arcanjo, Ingrid Virginia de Oliveira Sena, Adonai Carvalho Medeiros de Albuquerque, Bernardo Melo Neto, Lorena Citó Lopes Resende Santana, Naiguel Castelo Branco Silva, Maria Marilza Moita, Maria das Graccedil, as Freire de Medeiros, Maria José dos Santos Soares, Nilza Campos de, rade, Antocirc, nia Maria das Graccedil, as Lopes Cito,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoGomphrena globosa L. (Amaranthaceae) is used in folk medicine in the treatment of high blood pressure and other diseases. To confirm this popular use, ethanol extract from leaves of G. globosa L. was prepared by maceration and analyzed by some phytochemical and biological assays, including cardiovascular activity. The phytochemical screeningdetected the presence of saponins, alkaloids, reducing sugars and coumarins. The extract did not induce either lethality in the brine shrimp (Artemia salina Leach) bioassay orantimicrobial activity. The negative results for cytotoxic and antimicrobial assays indicated possible low cytotoxicity to the extract. In other hand, it promoted a hypotensive activity by significant reduction in arterial blood pressure without change heart rate, confirming the therapeutic use as antihypertensive for this plant. Key words: Gomphrena, Amaranthaceae, antihypertensive, cytotoxicity, Artemia salina.
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