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Imidazolium salts as antifungal agents: activity against emerging yeast pathogens, without human leukocyte toxicity

2013; Royal Society of Chemistry; Volume: 4; Issue: 11 Linguagem: Inglês

10.1039/c3md00222e

2040-2511

Henri Stephan Schrekker, Ricardo K. Donato, Alexandre Meneghello Fuentefría, Vanessa Zafaneli Bergamo, Luís Flávio Souza de Oliveira, Michel Mansur Machado,

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This study demonstrates the excellent in vitro antifungal activity profile of imidazolium ionic liquids (ILs) against species of opportunistic human mycoses. Several ILs were identified as more effective and less harmful than commercially available antifungal medications. Frequently, emerging yeast pathogens are resistant against commercial antifungal agents and, as a consequence, this class of imidazolium ILs represents a promising breakthrough in their treatment.