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The EUROCARE-5 study on cancer survival in Europe 1999–2007: Database, quality checks and statistical analysis methods

2015; Elsevier BV; Volume: 51; Issue: 15 Linguagem: Inglês

10.1016/j.ejca.2015.08.001

1879-0852

Silvia Rossi, Paolo Baili, Riccardo Capocaccia, M. Caldora, E. Carrani, Pamela Minicozzi, Daniela Pierannunzio, Mariano Santaquilani, Annalisa Trama, Claudia Allemani, Aurélien Belot, Carlotta Buzzoni, Matthias Lorez, Roberta De Angelis, Monika Hackl, N. Zielonke, Willi Oberaigner, E. Van Eycken, K. Henau, Z. Valerianova, Nadya Dimitrova, Mario Šekerija, Miroslav Zvolský, Ladislav Dušek, Hans H. Storm, Gerda Engholm, Margit Mägi, Tiiu Aareleid, Nea Malila, Karri Seppä, Michel Velten, X. Troussard, Véronique Bouvier, Guy Launoy, A.V. Guizard, Jean Faivre, Anne‐Marie Bouvier, P. Arveux, Marc Maynadié, Anne‐Sophie Woronoff, Michel Robaszkiewicz, Isabelle Baldi, Alain Monnereau, Brigitte Trétarre, Nadine Bossard, Aurélien Belot, Marc Colonna, F. Molinié, S. Bara, C. Schvartz, B. Lapôtre‐Ledoux, Pascale Grosclaude, Martin Meyer, Roland Stabenow, Sabine Luttmann, Andrea Eberle, Hermann Brenner, Alice Nennecke, Jutta Engel, G. Schubert-Fritschle, Joachim Kieschke, Jan Heidrich, Bernd Holleczek, Alexander Katalinic, Jón G. Jónasson, Laufey Tryggvadóttír, Harry Comber, Guido Mazzoleni, A. Bulatko, Carlotta Buzzoni, Adriano Giacomin, Angela Sardo, A. Mazzei, Stefano Ferretti, Emanuele Crocetti, Gianfranco Manneschi, Gemma Gatta, Milena Sant, H. Amash, C. Amati, Paolo Baili, Franco Berrino, S. Bonfarnuzzo, Laura Botta, Francesca Di Salvo, Roberto Foschi, C. Margutti, E. Meneghini, Pamela Minicozzi, Annalisa Trama, Diego Serraino, Antonella Zucchetto, Roberta De Angelis, M. Caldora, Riccardo Capocaccia, E. Carrani, Silvia Francisci, Sandra Mallone, Daniela Pierannunzio, P. Roazzi, Silvia Rossi, Mariano Santaquilani, Andrea Tavilla, M. Natali F. Pannozzo, L Bonelli, Marina Vercelli, Valerio Gennaro, Paolo Ricci, M. Autelitano, G. Randi, Maurizio Ponz de Leòn, C. Marchesi, Claudia Cirilli, Mario Fusco, M.F. Vitale, M. Usala, A. Traina, Maurizio Zarcone, Francesco Vitale, Rosanna Cusimano, Maria Michiara, ­Rosario ­Tumino, Paolo Giorgi Rossi, Massimo Vicentini, Fabio Falcini, Antonio Iannelli, O. Sechi, R. Cesaraccio, Silvano Piffer, A Madeddu, F. Tisano, S. Maspero, A.C. Fanetti, Roberto Zanetti, Stefano Rosso, P. Candela, T. Scuderi, Fabrizio Stracci, Andrea Rocca, Giovanna Tagliabue, Paolo Contiero, Angelo Paolo Dei Tos, Sandro Tognazzo, Santa Pildava, Giedrė Smailytė, Neville Calleja, R. Micallef, Tom Børge Johannesen, Jadwiga Rachtan, Stanisław Góźdż, Ryszard Mężyk, Jerzy Błaszczyk, Kamila Kępska, Magdalena Bielska‐Lasota, G. Forjaz de Lacerda, María José Bento, Luís Antunes, A. Miranda, A. Mayer-da-Silva, Florian Nicula, Daniela Coza, C. Safaei Diba, Maja Primic‐Žakelj, E. Almar, Antonio Navareño Mateos, M. Errezola, Nerea Larrañaga, A. Torrella-Ramos, J.M. Díaz García, A.I. Marcos-Navarro, Rafael Marcos‐Gragera, L. Vilardell, María‐José Sánchez, Esther Molina‐Montes, Carmen Navarro, María‐Dolores Chirlaque, C. Moreno-Iribas, Eva Ardanáz, Jaume Galcerán, M. Carulla, Mats Lambe, S. Khan, Seyed Mohsen Mousavi, Christine Bouchardy, M. Usel, S.M. Ess, H. Frick, Matthias Lorez, S.M. Ess, C. Herrmann, Andrea Bordoni, Alessandra Spitale, Isabelle Konzelmann, Vincent K.Y. Ho, Sabine Siesling, Michel P. Coleman, Claudia Allemani, Bernard Rachet, Julia Verne, N. Easey, Gill Lawrence, Teresa Morán, Jem Rashbass, M. Roche, J. Wilkinson, Anna Gavin, Deirdre Fitzpatrick, David Brewster, Dyfed Huws, Peter D. White, R. Otter,

Global Cancer Incidence and Screening

Background Since 25 years the EUROCARE study monitors the survival of cancer patients in Europe through centralised collection, quality check and statistical analysis of population-based cancer registries (CRs) data. The European population covered by the study increased remarkably in the latest round. The study design and statistical methods were also changed to improve timeliness and comparability of survival estimates. To interpret the EUROCARE-5 results on adult cancer patients better here we assess the impact of these changes on data quality and on survival comparisons. Methods In EUROCARE-5 the survival differences by area were studied applying the complete cohort approach to data on nearly nine million cancer patients diagnosed in 2000–2007 and followed up to 2008. Survival time trends were analysed applying the period approach to data on about 10 million cancer cases diagnosed from 1995 to 2007 and followed up to 2008. Differently from EUROCARE-4, multiple primary cancers were included and relative survival was estimated with the Ederer II method. Results EUROCARE-5 covered a population of 232 million resident persons, corresponding to 50% of the 29 participating countries. The population coverage increased particularly in Eastern Europe. Cases identified from death certificate only (DCO) were on average 2.9%, range 0–12%. Microscopically confirmed cases amounted to over 85% in most CRs. Compared to previous methods, including multiple cancers and using the Ederer II estimator reduced survival estimates by 0.4 and 0.3 absolute percentage points, on average. Conclusions The increased population size and registration coverage of the EUROCARE-5 study ensures more robust and comparable estimates across European countries. This enlargement did not impact on data quality, which was generally satisfactory. Estimates may be slightly inflated in countries with high or null DCO proportions, especially for poor prognosis cancers. The updated methods improved the comparability of survival estimates between recently and long-term established registries and reduced biases due to informative censoring.