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Anxiolytic Effects of Erythrinian Alkaloids from Erythrina mulungu

2006; American Chemical Society; Volume: 70; Issue: 1 Linguagem: Inglês

10.1021/np060254j

1520-6025

Otávio Flausino, Luciana de Ávila Santos, Hugo Verli, Ana Maria Soares Pereira, Vanderlan da Silva Bolzani, Ricardo Luiz Nunes-de-Souza,

Biological and pharmacological studies of plants

One new erythrinian alkaloid derivative, (+)-11alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of 1H, 13C, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.