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Human pluripotent stem cells as tools for neurodegenerative and neurodevelopmental disease modeling and drug discovery

2015; Taylor & Francis; Volume: 10; Issue: 6 Linguagem: Inglês

10.1517/17460441.2015.1037737

1746-045X

Stefania Corti, Irene Faravelli, Marina Cardano, Luciano Conti,

Neuroscience and Neural Engineering

Introduction: Although intensive efforts have been made, effective treatments for neurodegenerative and neurodevelopmental diseases have not been yet discovered. Possible reasons for this include the lack of appropriate disease models of human neurons and a limited understanding of the etiological and neurobiological mechanisms. Recent advances in pluripotent stem cell (PSC) research have now opened the path to the generation of induced pluripotent stem cells (iPSCs) starting from somatic cells, thus offering an unlimited source of patient-specific disease-relevant neuronal cells.