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Trafficking of B Cell Antigen in Lymph Nodes

2011; Annual Reviews; Volume: 29; Issue: 1 Linguagem: Inglês

10.1146/annurev-immunol-031210-101255

1545-3278

Santiago González, Søren E. Degn, Lisa A. Pitcher, Matthew C. Woodruff, Balthasar A. Heesters, Michael C. Carroll,

Immune Cell Function and Interaction

The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memory, and elimination of self-reactive clones ( 2 ). The experimental demonstration by Nossal & Lederberg ( 3 ) that B lymphocytes bear receptors for a single antigen raised the central question of where B lymphocytes encounter antigen. This question has remained mostly unanswered until recently. Advances in techniques such as multiphoton intravital microscopy ( 4 , 5 ) have provided new insights into the trafficking of B cells and their antigen. In this review, we summarize these advances in the context of our current view of B cell circulation and activation.