Effects of lonidamine on the membrane electrical properties of Ehrlich ascites tumor cells
1991; Wiley; Volume: 291; Issue: 2 Linguagem: Inglês
10.1016/0014-5793(91)81275-d
ISSN1873-3468
AutoresMaria Teresa Santini, C. Cametti, Pietro L. Indovina, Walter Malorni, Marcello Benassi, Francesco Gentile, Susanna Castiglione, Aristide Floridi,
Tópico(s)Electrochemical Analysis and Applications
ResumoThe effects of lonidamine on membrane electrical properties of Ehrlich ascites tumor cells are investigated. Using a dielectric relaxation technique based on the Maxwell-Wagner effect and elaborated by a 'single-shell' fitting procedure, the data indicate that both membrane conductivity and membrane permittivity increase after treatment of these cells with lonidamine while the conductivity of the cytosol remains unchanged. Changes in membrane proteins and/or lipids are suggested which lead to altered membrane structure and/or function.
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