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Osteocyte control of osteoclastogenesis

2012; Elsevier BV; Volume: 54; Issue: 2 Linguagem: Inglês

10.1016/j.bone.2012.08.121

8756-3282

Charles A. O’Brien, Tomoki Nakashima, Hiroshi Takayanagi,

Bone health and osteoporosis research

Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine RANKL involved in osteoclast formation in cancellous bone. The goal of this review is to discuss these and other studies that reveal mechanisms whereby osteocytes control osteoclast formation and thus bone resorption.