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Nucleotide Cross‐Linking Induced by Photoreactions of Platinum( IV )–Azide Complexes

2003; Wiley; Volume: 42; Issue: 3 Linguagem: Inglês

10.1002/anie.200390110

1521-3773

P Müller, Björn Schröder, John A. Parkinson, Nicole A. Kratochwil, R.A. Coxall, Andrew Parkin, Simon Parsons, Peter J. Sadler,

Lanthanide and Transition Metal Complexes

Visible light irradiation of inert [PtIV(diam(m)ine)(diazide)] complexes leads to reductive elimination of the azide ligands, production of N2, and formation of bifunctional adducts with guanine bases of the type which are lethal to cancer cells (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z19849_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.