Portal de Periódicos da CAPES

Synthesis of New Cyano-Substituted bis-Benzothiazolyl Arylfurans and Arylthiophenes

2003; Multidisciplinary Digital Publishing Institute; Volume: 8; Issue: 3 Linguagem: Inglês

10.3390/80300342

1433-1373

Livio Racané, Vesna Tralić‐Kulenović, David W. Boykin, Grace Karminski‐Zamola,

Synthesis and Biological Evaluation

The new compounds 2-[4-(6-cyanobenzothiazol-2-yl)phenyl]-5-(6-cyano-benzothiazol-2-yl)furan (6a) and 2-[4-(6-Cyanobenzothiazol-2-yl)phenyl]-5-(6-cyano-benzothiazol-2-yl)thiophene (6b) were synthesized by multi-step reactions from the corresponding 2-furan and 2-thiophene carboxaldehydes (route A), as well as from 2-furan and 2- thiophene carboxylic acids (route B). Route B involves one less step than route A, but the overall yields of the reactions are considerably lower.