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BIBTEX RIS

In Vitro Activity of BMS-790052 on Hepatitis C Virus Genotype 4 NS5A

2011; American Society for Microbiology; Volume: 56; Issue: 3 Linguagem: Inglês

10.1128/aac.06169-11

ISSN

1098-6596

Autores

Chunfu Wang, Lingling Jia, Haichang Huang, Dike Qiu, Lourdes Valera, Xin Huang, Jin-Hua Sun, Peter T. Nower, Donald R. O’Boyle, Min Gao, Robert A. Fridell,

Tópico(s)

Liver Disease Diagnosis and Treatment

Resumo

The antiviral profile of BMS-790052, a potent hepatitis C virus (HCV) replication complex inhibitor targeting nonstructural protein NS5A, is well characterized for HCV genotype-1. Here, we report that BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with 50% effective concentrations (EC(50)s) ranging from 7 to 13 pM. NS5A residue 30 was an important site for BMS-790052-selected resistance in the hybrid replicons. Our results support the potential of BMS-790052 as a valuable component of combination therapy for HCV genotype-4 chronic infection.

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