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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

In Vitro Antimycobacterial Spectrum of a Diarylquinoline ATP Synthase Inhibitor

2007; American Society for Microbiology; Volume: 51; Issue: 11 Linguagem: Inglês

10.1128/aac.00181-07

ISSN

1098-6596

Autores

Emma Huitric, Peter Verhasselt, Koen Andries, Sven Hoffner,

Tópico(s)

Cancer therapeutics and mechanisms

Resumo

The diarylquinoline R207910 is in clinical development for tuberculosis treatment. The MIC(50) for 41 drug-susceptible and 44 multidrug-resistant Mycobacterium tuberculosis clinical isolates was 0.032 microg/ml. Out of 20 additional mycobacterial species, three were found to be naturally resistant to R207910 and were shown to exhibit a polymorphism in their atpE genes.

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