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Role of carbonic anhydrases in pathogenic micro-organisms: a focus on Aspergillus fumigatus

2013; Microbiology Society; Volume: 63; Issue: 1 Linguagem: Inglês

10.1099/jmm.0.064444-0

1473-5644

Jaqueline Moisés Tobal, Márcia Eliana da Silva Ferreira,

Phenothiazines and Benzothiazines Synthesis and Activities

Aspergillus fumigatus is a ubiquitous saprophytic fungus responsible for organic material decomposition, and plays an important role in recycling environmental carbon and nitrogen. Besides its important role in the environment, this fungus has been reported as one of the most important fungal pathogens in immunocompromised patients. Due to changes in CO 2 concentration that some pathogens face during the infection process, studies have been undertaken to understand the pathogenic roles of carbonic anhydrases (CAs), well-known CO 2 hydration catalytic enzymes. As a basis for a discussion of the possible roles of CAs in A. fumigatus pathogenicity, this review describes the main characteristics of the A. fumigatus infection and the challenges for its treatment. In addition, it gathers findings from studies with CA inhibitor drugs as anti-infective agents in different pathogens.