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Diabetic Cystopathy Correlates With a Long-Term Decrease in Nerve Growth Factor Levels in The Bladder and Lumbosacral Dorsal Root Ganglia

2002; Lippincott Williams & Wilkins; Volume: 168; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(05)64636-8

1527-3792

Katsumi Sasaki, Michael B. Chancellor, Michael W. Phelan, Teruhiko Yokoyama, Matthew O. Fraser, Satoshi Seki, Kazuyuki Kubo, Hiromi Kumon, William C. de Groat, Naoki Yoshimura,

Sympathectomy and Hyperhidrosis Treatments

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Sep 2002Diabetic Cystopathy Correlates With a Long-Term Decrease in Nerve Growth Factor Levels in The Bladder and Lumbosacral Dorsal Root Ganglia Katsumi Sasaki, Michael B. Chancellor, Michael W. Phelan, Teruhiko Yokoyama, Matthew O. Fraser, Satoshi Seki, Kazuyuki Kubo, Hiromi Kumon, William C. de Groat, and Naoki Yoshimura Katsumi SasakiKatsumi Sasaki , Michael B. ChancellorMichael B. Chancellor , Michael W. PhelanMichael W. Phelan , Teruhiko YokoyamaTeruhiko Yokoyama , Matthew O. FraserMatthew O. Fraser , Satoshi SekiSatoshi Seki , Kazuyuki KuboKazuyuki Kubo , Hiromi KumonHiromi Kumon , William C. de GroatWilliam C. de Groat , and Naoki YoshimuraNaoki Yoshimura View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64636-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: It has been proposed that a deficiency in the axonal transport of nerve growth factor (NGF) may have an important role in inducing diabetic neuropathy, which contributes to diabetic cystopathy. Therefore, in streptozotocin (Sigma Chemical Co., St. Louis, Missouri) induced diabetic rats we investigated the relationship of bladder function with NGF levels in the bladder and lumbosacral dorsal root ganglia, which contain afferent neurons innervating the bladder. Materials and Methods: At 6 and 12 weeks after the induction of diabetes with streptozotocin (65 mg./kg. intraperitoneally) the effects of diabetes on Aδ afferent fiber dependent, conscious voiding were evaluated by metabolic cage measurements and awake cystometry. The effects of diabetes on C-fiber mediated bladder nociceptive responses were also investigated by cystometry with intravesical instillation of 0.25% acetic acid in the rats under urethane anesthesia. NGF levels in the bladder and L6 to S1 dorsal root ganglia were measured by enzyme-linked immunosorbent assay 3, 6, 9 and 12 weeks after streptozotocin injection. Results: In diabetic rats NGF levels in the bladder and L6 to S1 dorsal root ganglia were significantly decreased 12 weeks after streptozotocin injection (p <0.01). In cystometry and metabolic cage studies bladder capacity and post-void residual volume were significantly increased 12 weeks after streptozotocin injection (p <0.01). 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Fraser More articles by this author Satoshi Seki More articles by this author Kazuyuki Kubo More articles by this author Hiromi Kumon More articles by this author William C. de Groat More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...