Eye color and the prediction of complex phenotypes from genotypes
2009; Elsevier BV; Volume: 19; Issue: 5 Linguagem: Inglês
10.1016/j.cub.2009.01.027
ISSN1879-0445
AutoresFan Liu, Kate van Duijn, Johannes R. Vingerling, Albert Hofman, André G. Uitterlinden, A. Cecile J.W. Janssens, Manfred Kayser,
Tópico(s)Genetic and phenotypic traits in livestock
ResumoPredicting complex human phenotypes from genotypes has recently gained tremendous interest in the emerging field of consumer genomics, particularly in light of attempting personalized medicine [1Janssens A.C. van Duijn C.M. Genome-based prediction of common diseases: advances and prospects.Hum. Mol. Genet. 2008; 17: R166-R173Crossref PubMed Scopus (270) Google Scholar, 2Brand A. Brand H. Schulte in den Baumen T. The impact of genetics and genomics on public health.Eur. J. Hum. Genet. 2008; 16: 5-13Crossref PubMed Scopus (78) Google Scholar]. So far, however, this approach has not been shown to be accurate, thus limiting its practical applications [3Janssens A.C. Gwinn M. Bradley L.A. Oostra B.A. van Duijn C.M. Khoury M.J. A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions.Am. J. Hum. Genet. 2008; 82: 593-599Abstract Full Text Full Text PDF PubMed Scopus (240) Google Scholar, 4Haga S.B. Khoury M.J. Burke W. Genomic profiling to promote a healthy lifestyle: not ready for prime time.Nat. Genet. 2003; 34: 347-350Crossref PubMed Scopus (143) Google Scholar]. Here, we used human eye (iris) color of Europeans as an empirical example to demonstrate that highly accurate genetic prediction of complex human phenotypes is feasible. Moreover, the six DNA markers we identified as major eye color predictors will be valuable in forensic studies.
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