The disposition and pharmacokinetics of Dioscorea nipponica Makino extract in rats
2008; Academic Journals; Volume: 7; Issue: 22 Linguagem: Inglês
10.4314/ajb.v7i22.59499
ISSN1684-5315
AutoresHongqiang Ren, Jian Ping Chen, Bin Tan, Dongmei Wang, Shu Hai Lin, Y. P. Zhang, T. Y. Wings Loo, H. S. Barry Yeung, Jin Miao-zhen, Xiaofang Li,
Tópico(s)Phytochemistry and Bioactive Compounds
Resumo3 H labeled TSD at a single dose ratio of 80 mg TSD per 1 kg rat. Blood samples and feces were collected at different time points to measure the level of TSD activity. At the final time point, determination of the disposition of TSD in lung, kidney, heart, liver, adrenal, and small intestine were performed. From the blood samples' emission of radioactivity, pharmacokinetic parameters were derived as T1/2 = 33.33 ± 4.48 h, Tmax = 6.5 ± 0.71 h, AUC = 119400 ± 421097.67, and Cmax = 2643.33 ± 192.26 dpm/ml. There was 51.609% of 3 H labeled substance excreted in 24 h. These results suggested that blood concentration of 3 H-TSD was extremely low and the majority of TSD was excreted in the feces. The TSD was extensively distributed to multi- tissues. The radioactivity level was measured to be the highest in the liver, adrenal gland, and wall of the gastrointestinal tract. The radioactivity of TSD was still being detected in blood after 96 h. This showed TSD was excreted in vivo very slowly.
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