Hydrolysis of arbutin to hydroquinone by human skin bacteria and its effect on antioxidant activity
2008; Wiley; Volume: 7; Issue: 3 Linguagem: Inglês
10.1111/j.1473-2165.2008.00387.x
ISSN1473-2165
AutoresSeo‐Hyun Bang, Sang‐Jun Han, Dong‐Hyun Kim,
Tópico(s)Ginseng Biological Effects and Applications
ResumoArbutin, the beta-D-glucopyranoside of hydroquinone, is a skin whitening cosmetic ingredient. Compared with arbutin, hydroquinone is a more potent skin lightening agent, but shows cytotoxicity, nephrotoxicity, and genotoxicity. To evaluate whether skin microflora can hydrolyze arbutin to hydroquinone, we measured the hydrolytic activity of the main skin microflora: Staphylococcus epidermidis and Staphylococcus aureus. All strains hydrolyzed arbutin, with activities of 0.16-4.51 nmol/min/mg. The hydrolyzed hydroquinone showed more potent 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and tyrosinase inhibition than arbutin. These findings suggest that normal skin microflora may increase the skin lightening effect of arbutin due to the antioxidant action of hydroquinone.
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