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INTEGRATION OF THE HEART RHYTHMOGENESIS LEVELS: HEART RHYTHM GENERATOR IN THE BRAIN

2005; Imperial College Press; Volume: 04; Issue: 02 Linguagem: Inglês

10.1142/s0219635205000793

1757-448X

Pokrovskiĭ Vm,

Neuroscience of respiration and sleep

Journal of Integrative NeuroscienceVol. 04, No. 02, pp. 161-168 (2005) Short CommunicationsNo AccessINTEGRATION OF THE HEART RHYTHMOGENESIS LEVELS: HEART RHYTHM GENERATOR IN THE BRAINVLADIMIR M. POKROVSKIIVLADIMIR M. POKROVSKIINormal Physiology Department, Kuban State Medical Academy, Sedin St., 4, Krasnodar, 350063, Russiahttps://doi.org/10.1142/S0219635205000793Cited by:11 Next AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractWe propose that along with the intracardiac pacemaker, a generator of cardiac rhythm exists in the central nervous system — in the efferent structures of the cardiovascular center of the medullar oblongata. Signals in the medulla oblongata arise as a result of the hierarchic interaction of the brain structures. Neural signals originating there in the form of bursts of impulses conduct to the heart along the vagus nerves and after interaction with cardiac pacemaker structures, cause generation of the cardiac pulse in exact accordance with the frequency of "neural bursts". The intrinsic cardiac rhythm generator (the sinus node) is a life-sustaining factor that maintains the heart pumping function when the central nervous system is in a stage of deep inhibition, (e.g., under anesthesia or during unconsciousness). The brain generator is the factor that provides heart adaptive reactions in behaving organism. The integration of the two levels of rhythmogenesis in the brain and heart provides reliability and functional perfection of the cardiac rhythm generation system in the whole organism.Keywords:Heart rhythmduplicated controlcardiorespiratory synchronizationheart rhythm generator in the brain References K. Goto, J. Physiol. Soc. Jap. 41, 8 (1979). ISI, Google ScholarP. G. Katonaet al., Am. J. 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Google ScholarA. A. Zubkov, B. Exp. Biol. Medt. 1(1), 73 (1936). ISI, Google Scholar FiguresReferencesRelatedDetailsCited By 11Asymmetry of synchronisation tongue in persistent sodium plus potassium neuron modelI.A. Khovanov, S. Perry and N.A. Khovanova1 Feb 2022 | Communications in Nonlinear Science and Numerical Simulation, Vol. 105Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node)Pavel A. Galenko-Yaroshevsky, Anatoly A. Nechepurenko, Tatiana G. Pokrovskaya, Nikolai L. Shimonovsky and Alexander S. Dukhanin et al.24 September 2021 | Research Results in Pharmacology, Vol. 7, No. 3Control of heart rate through guided high-rate breathingSean Perry, Natasha A. Khovanova and Igor A. Khovanov7 February 2019 | Scientific Reports, Vol. 9, No. 1Central pattern generators in the brainstem and spinal cord: an overview of basic principles, similarities and differencesInge Steuer and Pierre A. 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Pokrovskii and O. G. Kompaniets24 October 2008 | Bulletin of Experimental Biology and Medicine, Vol. 145, No. 6 Recommended Vol. 04, No. 02 Metrics History Received 26 October 2004 Accepted 18 February 2005 KeywordsHeart rhythmduplicated controlcardiorespiratory synchronizationheart rhythm generator in the brainPDF download