Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
2010; Nature Portfolio; Volume: 13; Issue: 4 Linguagem: Inglês
10.1038/nn.2511
ISSN1546-1726
AutoresMartin Fuhrmann, Tobias Bittner, Christian Jung, Steffen Burgold, Richard Page, Gerda Mitteregger, Christian Haass, Frank M. LaFerla, Hans A. Kretzschmar, Jochen Herms,
Tópico(s)Immune Response and Inflammation
ResumoMicroglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease by phagocytosing amyloid-beta. Two-photon in vivo imaging of neuron loss in the intact brain of living Alzheimer's disease mice revealed an involvement of microglia in neuron elimination, indicated by locally increased number and migration velocity of microglia around lost neurons. Knockout of the microglial chemokine receptor Cx3cr1, which is critical in neuron-microglia communication, prevented neuron loss.
Referência(s)