Synthetic Disialyl Hexasaccharides Protect Neonatal Rats from Necrotizing Enterocolitis
2014; Wiley; Volume: 53; Issue: 26 Linguagem: Inglês
10.1002/anie.201403588
ISSN1521-3773
AutoresHai Yu, Kam Lau, Vireak Thon, Chloe Autran, Evelyn Jantscher‐Krenn, Mengyang Xue, Yanhong Li, Go Sugiarto, Jingyao Qu, Shengmao Mu, Ding Li, Lars Bode, Xi Chen,
Tópico(s)Pediatric Hepatobiliary Diseases and Treatments
ResumoAbstract Two novel synthetic α2–6‐linked disialyl hexasaccharides, disialyllacto‐ N ‐neotetraose (DSLNnT) and α2–6‐linked disialyllacto‐ N ‐tetraose (DS′LNT), were readily obtained by highly efficient one‐pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS′LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.
Referência(s)