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Double gammopathies: Incidence and clinical course of 20 patients

1986; Wiley; Volume: 36; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0609.1986.tb02658.x

0036-553X

Torbjörn Nilsson, Bo Norberg, Olle Rudolph, L. Jacobsson,

HIV/AIDS drug development and treatment

The presence of 2 M‐components in single patients (double gammopathy) was studied retrospectively by means of the electrophoresis files in Umea (serving a population of approximately 150000 inhabitants). During the 11‐year period 1974–1984, 109000 electrophoreses were performed, an nig which 1034 patients with gammopathy were found. Of these, 20 (2%) had double gammopathy; 3 were associated with lymphoma, 7 with myelomatosis, 9 with monoclonal gammopathy of undetermined significance (MGUS), and 1 with lupus erythematosus disseminatus. It is suggested that one subgroup of double gammopathy (6 patients) had a neoplastic cell clone combined with a normally regulated cell line, the latter marked by a transient M‐component. Another subgroup (14 patients) seems to have 2 coexisting different neoplastic cell lines, with persistent double gammopathy.