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Characteristics and outcome of pediatric non-hodgkin lymphoma patients with ovarian infiltration at presentation

2013; Wiley; Volume: 60; Issue: 12 Linguagem: Inglês

10.1002/pbc.24582

1545-5017

Wendy van Dorp, Catherine Owusuaa, Joop S.E. Laven, Marry M. van den Heuvel‐Eibrink, Auke Beishuizen,

Lymphoma Diagnosis and Treatment

Pediatric Blood & CancerVolume 60, Issue 12 p. 2054-2059 Research Article Characteristics and outcome of pediatric non-hodgkin lymphoma patients with ovarian infiltration at presentation Wendy van Dorp MD, Wendy van Dorp MD Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The Netherlands Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The NetherlandsSearch for more papers by this authorCatherine Owusuaa, Catherine Owusuaa Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The NetherlandsSearch for more papers by this authorJoop S.E. Laven MD, PhD, Joop S.E. Laven MD, PhD Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The NetherlandsSearch for more papers by this authorMarry M. van den Heuvel-Eibrink MD, PhD, Corresponding Author Marry M. van den Heuvel-Eibrink MD, PhD Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The Netherlands Correspondence to: Marry M. van den Heuvel-Eibrink, Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center, Sophia's Children's Hospital, Room Na 16.13, Dr. Molewaterplein 60, Rotterdam 3015 GJ, The Netherlands. E-mail: [email protected]Search for more papers by this authorAuke Beishuizen MD, PhD, Auke Beishuizen MD, PhD Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The NetherlandsSearch for more papers by this author Wendy van Dorp MD, Wendy van Dorp MD Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The Netherlands Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The NetherlandsSearch for more papers by this authorCatherine Owusuaa, Catherine Owusuaa Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The NetherlandsSearch for more papers by this authorJoop S.E. Laven MD, PhD, Joop S.E. Laven MD, PhD Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The NetherlandsSearch for more papers by this authorMarry M. van den Heuvel-Eibrink MD, PhD, Corresponding Author Marry M. van den Heuvel-Eibrink MD, PhD Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The Netherlands Correspondence to: Marry M. van den Heuvel-Eibrink, Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center, Sophia's Children's Hospital, Room Na 16.13, Dr. Molewaterplein 60, Rotterdam 3015 GJ, The Netherlands. E-mail: [email protected]Search for more papers by this authorAuke Beishuizen MD, PhD, Auke Beishuizen MD, PhD Department of Pediatric Oncology/Hematology, Erasmus MC University Medical Center-Sophia's Children's Hospital, Rotterdam, The NetherlandsSearch for more papers by this author First published: 19 July 2013 https://doi.org/10.1002/pbc.24582Citations: 6 Conflict of interest: Nothing to declare. Wendy van Dorp and Catherine Owusuaa contributed equally to this work. Marry M. van den Heuvel-Eibrink and Auke Beishuizen contributed equally to this work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Background Ovarian infiltration in pediatric non-Hodgkin lymphoma (NHL) at presentation is rare and information on outcome is scarce and mainly based on case reports and small series. Procedure Evaluation of clinical characteristics and outcome of ovarian infiltrated pediatric NHL cases of a single center, and an extensive review of the all cases reported so far in literature. Results At presentation, 6/60 female NHL cases of our center had ovarian infiltration, and combining these cases with earlier case reports, a total of 42 cases were identified. Median age at presentation was 10.9 years (range 0–18), and all but one had a B-cell immunophenotype, with 32/42 cases being classified as Burkitt. Bilateral involvement was reported in 26/41 cases, of which 22 were bilaterally ovariectomized as first treatment. All cases were treated with chemotherapy. Relapses were reported in 9/36 and death in 16/36. After follow-up in our center (median 13.4 years), in 2 cases anti-Müllerian hormone (AMH) values were available (2.1 and 0.9 µg/L), in non-ovarian cases median 2.2 µg/L. Conclusions We conclude that in case of ovarian tumors with negative markers, NHL should be considered in order to avoid unnecessary surgery. Pediatr Blood Cancer 2013;60:2054–2059. © 2013 Wiley Periodicals, Inc. Citing Literature Volume60, Issue12December 2013Pages 2054-2059 RelatedInformation