Artigo Revisado por pares

Cyclosporin A Suppresses Insulin Autoantibodies and Heterologous Insulin Antibodies in Type I Diabetic Children

1988; American Diabetes Association; Volume: 37; Issue: 8 Linguagem: Inglês

10.2337/diab.37.8.1049

ISSN

1939-327X

Autores

Luís Castaño, Christian Boîtard, Pierre-François Bougnères,

Tópico(s)

Diabetes Treatment and Management

Resumo

We report that cyclosporin A (CsA) suppresses the insulin autoantibodies that are present before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic children. CsA also reversibly blocks the production of antibodies after exogenous insulin injection, whereas high titers of heterologous insulin antibody are observed in all type I patients not receiving CsA.

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