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Remarkable Cooperativity between a ZnII Ion and Guanidinium/Ammonium Groups in the Hydrolysis of RNA

2002; Wiley; Volume: 41; Issue: 21 Linguagem: Inglês

10.1002/1521-3773(20021104)41

1521-3773

Hassan Aït‐Haddou, Jun Sumaoka, Sheryl L. Wiskur, J.F. Folmer-Andersen, Eric V. Anslyn,

Chemical Synthesis and Analysis

Angewandte Chemie International EditionVolume 41, Issue 21 p. 4013-4016 Communication Remarkable Cooperativity between a ZnII Ion and Guanidinium/Ammonium Groups in the Hydrolysis of RNA† Hassan Aït-Haddou, Hassan Aït-Haddou Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this authorJun Sumaoka, Jun Sumaoka Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this authorSheryl L. Wiskur, Sheryl L. Wiskur Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this authorJ. Frantz Folmer-Andersen, J. Frantz Folmer-Andersen Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this authorEric V. Anslyn, Eric V. Anslyn anslyn@ccwf.cc.utexas.edu Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this author Hassan Aït-Haddou, Hassan Aït-Haddou Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this authorJun Sumaoka, Jun Sumaoka Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this authorSheryl L. Wiskur, Sheryl L. Wiskur Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this authorJ. Frantz Folmer-Andersen, J. Frantz Folmer-Andersen Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this authorEric V. Anslyn, Eric V. Anslyn anslyn@ccwf.cc.utexas.edu Department of Chemistry and Biochemistry The University of Texas at Austin Austin, TX 78712 (USA) Fax: (+1) 512-471-7791Search for more papers by this author First published: 31 October 2002 https://doi.org/10.1002/1521-3773(20021104)41:21 3.0.CO;2-YCitations: 85 † We gratefully acknowledge the National Science Foundation for the support of this work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Cooperation is the key! Multifunctional catalysis with cooperativity approaching that found for enzymes is reported in the hydrolysis of RNA using a synthetic catalyst that includes one zinc atom and two guanidinium groups (see picture). Citing Literature Volume41, Issue21November 4, 2002Pages 4013-4016 RelatedInformation