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Microwave Assisted Synthesis of Some Pyrimidine Derivatives Using Polyphosphate Ester (PPE) in Ceramic Bath

2003; Taylor & Francis; Volume: 178; Issue: 6 Linguagem: Inglês

10.1080/10426500307892

1563-5325

Naser Foroughifar, Akbar Mobinikhaledi, H. FathinejadJirandehi,

Synthesis and biological activity

Pyrimidine derivatives, 4a-4m , were synthesized in high yield using a newly developed microwave-assisted cyclocondensation reaction of g -ketoester, aryl aldehyde, and (thio)urea. In all of these Biginelli reactions, a mixture of the appropriate g -ketoester, aryl aldehyde, and (thio)urea were subjected to microwave irradiation by using polyphosphate ester (PPE) as a reaction moderator. 1 H NMR and IR spectroscopies were used for characterization of compounds 4a-4m .