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Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides

2010; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 11 Linguagem: Inglês

10.3390/molecules15118251

1433-1373

Eun Mi Lee, Seung Sik Lee, Byung Yeoup Chung, Jae‐Young Cho, In Chul Lee, So Ra Ahn, Soo Jeung Jang, Tae Ho Kim,

Pharmacology and Obesity Treatment

Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-ß-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1-5 showed potent inhibitory effects on pancreatic lipase, with IC₅₀ values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.