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Inhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels—Brief Report

2011; Lippincott Williams & Wilkins; Volume: 32; Issue: 3 Linguagem: Inglês

10.1161/atvbaha.111.238113

1524-4636

Pei Zhang, Angela Huang, Jacopo Ferruzzi, Robert P. Mecham, Barry Starcher, George Tellides, Jay D. Humphrey, Frank J. Giordano, Laura E. Niklason, William C. Sessa,

Circular RNAs in diseases

Objective— The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and Results— miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels. Conclusion— miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.