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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Humoral and cellular immune responses in dogs with inapparent natural Leishmania infantum infection

2011; Elsevier BV; Volume: 190; Issue: 2 Linguagem: Inglês

10.1016/j.tvjl.2011.04.005

ISSN

1532-2971

Autores

Wendel Coura‐Vital, Marcos José Marques, Rodolfo Cordeiro Giunchetti, Andréa Teixeira−Carvalho, Nádia das Dores Moreira, Juliana Vitoriano-Souza, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro, Rodrigo Corrêa‐Oliveira, O. A. Martins‐Filho, Mariângela Carneiro, Alexandre Barbosa Reis,

Tópico(s)

Toxin Mechanisms and Immunotoxins

Resumo

Molecular analysis, serology and immunophenotyping for T lymphocytes and their subsets, B lymphocytes and monocytes were performed on dogs naturally infected with Leishmania infantum. Animals were categorised as asymptomatic dogs I (AD-I), with negative serology and positive molecular results, and asymptomatic dogs II (AD-II), with positive serology and positive molecular results, and these were compared to symptomatic dogs (SD) and control dogs (CD). AD-I exhibited immunophenotypic features similar to those of CD, including isotype profiles and concentrations of monocytes. Similar biomarkers were found in AD-II and SD, such as, higher levels of immunoglobulins IgG, IgG2, IgM and IgA and higher concentrations of eosinophils. High frequencies of T lymphocytes and CD4(+) T cells were observed in both AD-I and AD-II compared to SD, whereas CD8(+) T cells were higher only in AD-II compared with SD. Analysis of B lymphocytes revealed an increased frequency of this cell type only in AD-II animals compared with SD. Asymptomatic dogs appear to have a dichotomous infection spectrum that can influence the humoral and cellular immunological status during canine visceral leishmaniasis.

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