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Nitric oxide releasing derivatives of tolfenamic acid with anti-inflammatory activity and safe gastrointestinal profile

2005; Elsevier BV; Volume: 13; Issue: 23 Linguagem: Inglês

10.1016/j.bmc.2005.07.049

1464-3391

George N. Ziakas, Eleni A. Rekka, Antonios Gavalas, Phaedra Eleftheriou, Karyofillis C. Tsiakitzis, Panos N. Kourounakis,

Nitric Oxide and Endothelin Effects

Tolfenamic acid esters with nitrooxyalcohols are synthesized. They are anti-inflammatory agents reducing carrageenan rat paw edema, with low gastrointestinal and general toxicity. In vitro, they are nitric oxide donors, inhibitors of lipoxygenase and cyclooxygenases. A two to three carbon chain between carboxylic and nitric ester groups seems optimal for activity.