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BIBTEX RIS

Low bone density and low serum levels of soluble RANK ligand are associated with severe arterial calcification in patients with Takayasu arteritis

2005; Oxford University Press; Volume: 44; Issue: 12 Linguagem: Inglês

10.1093/rheumatology/kei045

1462-0332

Mailze Campos Bezerra, G. D. Calomeni, Valéria F. Caparbo, Eloísa Maria Mello Santiago Gebrim, Manoel de Souza Rocha, Rosa Maria Rodrigues Pereira,

Caveolin-1 and cellular processes

Objective. Takayasu arteritis (TA) is a chronic inflammatory disorder affecting the aorta and its branches. Vascular calcification has been described in 29–54% of cases of TA, although its aetiology remains unknown. Recently the osteoprotegerin/RANKL/RANK system has emerged as an important contributing factor to atherogenesis and osteogenesis. Our aim is to investigate the association between vascular calcification, bone mineral density (BMD) and the osteoprotegerin/RANK/RANKL system in TA.