Advances in self-assembled chitosan nanomaterials for drug delivery
2014; Elsevier BV; Volume: 32; Issue: 7 Linguagem: Inglês
10.1016/j.biotechadv.2014.07.007
ISSN1873-1899
AutoresYu Yang, Shengpeng Wang, Yitao Wang, Xiaohui Wang, Qun Wang, Meiwan Chen,
Tópico(s)Nanocomposite Films for Food Packaging
ResumoNanomaterials based on chitosan have emerged as promising carriers of therapeutic agents for drug delivery due to good biocompatibility, biodegradability, and low toxicity. Chitosan originated nanocarriers have been prepared by mini-emulsion, chemical or ionic gelation, coacervation/precipitation, and spray-drying methods. As alternatives to these traditional fabrication methods, self-assembled chitosan nanomaterials show significant advantages and have received growing scientific attention in recent years. Self-assembly is a spontaneous process by which organized structures with particular functions and properties could be obtained without additional complicated processing or modification steps. In this review, we focus on recent progress in the design, fabrication and physicochemical aspects of chitosan-based self-assembled nanomaterials. Their applications in drug delivery of different therapeutic agents are also discussed in details.
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