Copper in cross-coupling reactions
2004; Elsevier BV; Volume: 248; Issue: 21-24 Linguagem: Inglês
10.1016/j.ccr.2004.09.014
ISSN1873-3840
AutoresI. P. Beletskaya, Andrei V. Cheprakov,
Tópico(s)Sulfur-Based Synthesis Techniques
ResumoIn the last decade, a number of methods using various copper complexes and salts to carry out cross-coupling reactions leading to the formation of Cheteroatom (CN, CO, CS, CP, CSe), CC, and Cmetal bonds have been proposed. These methods aim at overcoming the deficiencies of conventional copper-assisted substitution methods (Ullmann chemistry) due to dramatic softening of reaction conditions, extension of scope towards unactivated substrates and new types of nucleophiles, and increasing tolerance to sensitive functionality. On the other hand, the scope and selectivity of copper-assisted methods are often complimentary to the parallel palladium-catalyzed cross-coupling methods. Both the new features and drawbacks of the new family of synthetic protocols are discussed.
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