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Efeitos da administração de beta-bloqueador na remodelação ventricular induzida pelo tabagismo em ratos

2009; Sociedade Brasileira de Cardiologia (SBC); Volume: 92; Issue: 6 Linguagem: Inglês

10.1590/s0066-782x2009000600011

ISSN

1678-4170

Autores

Daniella R. Duarte, Lucienne C. Oliveira, Marcos Ferreira Minicucci, Paula S. Azevedo, Beatriz B. Matsubara, Luiz Shiguero Matsubara, Álvaro Oscar Campana, Sérgio Alberto Rupp de Paiva, Leonardo A. M. Zornoff,

Tópico(s)

Cardiac Fibrosis and Remodeling

Resumo

The role of the adrenergic system on ventricular remodeling induced by cigarette smoking is unknown.To investigate the influence of propranolol on ventricular remodeling induced by exposure to tobacco smoke.Rats were divided into three groups: 1) C, n=10--control group; 2) F, n=10--animals exposed to tobacco smoke; 3) BB, n=10--animals receiving propranolol and exposed to tobacco smoke (40 mg/kg/day). After 2 months, the animals underwent echocardiographic and morphometric analyses. One-way ANOVA (mean +/- standard deviation) or the Kruskal-Wallis test (median and interquartile interval) was used.Group BB showed a lower heart rate than group F (C = 358 +/- 74 bpm, F = 374 +/- 53 bpm, BB = 297 +/- 30; P = 0.02). Group F showed greater end-diastolic diameters (C = 18.6 +/- 3.4 mm/kg, F = 22.8 +/- 1.8 mm/kg, BB = 21.7 +/- 1.8 mm/kg; P = 0.003) and left ventricular (LV) end-systolic diameters (C = 8.6 +/- 2.1 mm/kg, F = 11.3 +/- 1.3 mm/kg, BB = 9.9 +/- 1.2 mm/kg; P = 0.004), adjusted for body weight (BW) and a tendency towards a lower ejection fraction (C = 0.90 +/- 0.03, F = 0.87 +/- 0.03, BB =0.90 +/- 0.02; P = 0.07) than group C. Group BB showed a tendency towards a lower LV/BW ratio than group F (C = 1.94 (1.87 - 1.97), F = 2.03 (1.9-2.1) mg/g, BB = 1.89 (1.86-1.94); P = 0.09).Administration of propranolol attenuated some of the variables of ventricular remodeling induced by the exposure to tobacco smoke in rats.

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