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Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells

2008; Wiley; Volume: 5; Issue: 1 Linguagem: Inglês

10.1002/smll.200800926

1613-6829

Igor I. Slowing, Kevin C.‐W. Wu, Juan L. Vivero‐Escoto, Victor S.‐Y. Lin,

Blood properties and coagulation

The hemolytic properties of amorphous silica and MCM-41-type mesoporous silica nanoparticles (MSNs) with rabbit red blood cells (RBCs) are compared. The amorphous silica exhibits a high hemolytic activity toward the RBCs. In contrast, a high biocompatibility between the MSNs and the RBCs is observed. The low hemolytic activity of the MSNs offers promising potential for various in vivo biotechnological applications. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.