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A new equation to estimate the glomerular filtration rate in children, adolescents and young adults

2013; Oxford University Press; Volume: 29; Issue: 5 Linguagem: Inglês

10.1093/ndt/gft277

1460-2385

Liesbeth Hoste, Laurence Dubourg, Luciano da Silva Selistre, V. de Souza, Bruno Ranchin, Aoumeur Hadj‐Aïssa, Pierre Cochat, Frank Martens, Hans Pottel,

Renal Diseases and Glomerulopathies

A new estimated glomerular filtration rate (eGFR) equation, designed for isotope dilution mass spectrometry-standardized serum creatinine (Scr), is presented for use in children, adolescent boys and girls and young adults.The new equation, eGFR = 107.3/(Scr/Q), is based on the concept of normalized Scr: Q is the normalization value and is considered as the Scr concentration for the average healthy child, adolescent or young adult of a specific height (L) and is modeled as a height-dependent polynomial of the fourth degree.The well-known Schwartz equation [eGFR = kL/Scr, k = 0.413 (Schwartz) or k = 0.373 (Schwartz-Lyon)] for children between 1 and 14 years can be seen as a special case of the new equation for which the Q-polynomial is simplified to a linear equation: Q = 0.0035 × L (cm). The new eGFR equation has been validated in a data set of n = 750 children, adolescents and young adults aged 10-25, against the true GFR (inulin method), and outperforms the selected (but most used) creatinine-based eGFR equations for children, mainly in the healthy GFR region.The new Q(height)-eGFR equation serves as an excellent screening tool for kidney disease in 1-25-year-old children, adolescents and young adults.