Hypereosinophilia associated with monosomy 7
1995; Elsevier BV; Volume: 80; Issue: 1 Linguagem: Inglês
10.1016/0165-4608(94)00138-2
ISSN1873-4456
AutoresNora Viniou, Xenophon Yataganas, D Abazis, George Paterakis, Stathis Vavourakis, Κώστας Σταματόπουλος, Marina Matzourani, Dimitris Loukopoulos, Constantinos Pángalos,
Tópico(s)Neutrophil, Myeloperoxidase and Oxidative Mechanisms
ResumoCytogenetic analysis of bone marrow cells from a patient with anemia, marked leukocytosis with eosinophilia, and thrombocytopenia showed monosomy 7 in all metaphases examined. The patient has refractory anemia (RA) according to FAB classification. Because of the hypereosinophilia of the patient, PCR technique was performed and no bcr-abl mRNA, specific for chronic myelogenous leukemia, was detected. Monosomy 7 has not been previously described in cases with hypereosinophilia. We assume, according to previous reports, that multiple genetic lesions can be involved in the pathogenesis of hypereosinophilia in this patient.
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